3,027 research outputs found
Scene-based imperceptible-visible watermarking for HDR video content
This paper presents the High Dynamic Range - Imperceptible Visible Watermarking for HDR video content (HDR-IVW-V) based on scene detection for robust copyright protection of HDR videos using a visually imperceptible watermarking methodology. HDR-IVW-V employs scene detection to reduce both computational complexity and undesired visual attention to watermarked regions. Visual imperceptibility is achieved by finding the region of a frame with the highest hiding capacities on which the Human Visual System (HVS) cannot recognize the embedded watermark. The embedded watermark remains visually imperceptible as long as the normal color calibration parameters are held. HDR-IVW-V is evaluated on PQ-encoded HDR video content successfully attaining visual imperceptibility, robustness to tone mapping operations and image quality preservation
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Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome.
Fragile X Syndrome (FXS), a common inheritable form of intellectual disability, is known to alter neocortical circuits. However, its impact on the diverse synapse types comprising these circuits, or on the involvement of astrocytes, is not well known. We used immunofluorescent array tomography to quantify different synaptic populations and their association with astrocytes in layers 1 through 4 of the adult somatosensory cortex of a FXS mouse model, the FMR1 knockout mouse. The collected multi-channel data contained approximately 1.6 million synapses which were analyzed using a probabilistic synapse detector. Our study reveals complex, synapse-type and layer specific changes in the neocortical circuitry of FMR1 knockout mice. We report an increase of small glutamatergic VGluT1 synapses in layer 4 accompanied by a decrease in large VGluT1 synapses in layers 1 and 4. VGluT2 synapses show a rather consistent decrease in density in layers 1 and 2/3. In all layers, we observe the loss of large inhibitory synapses. Lastly, astrocytic association of excitatory synapses decreases. The ability to dissect the circuit deficits by synapse type and astrocytic involvement will be crucial for understanding how these changes affect circuit function, and ultimately defining targets for therapeutic intervention
Deletions in the neuraminidase stalk region of H2N2 and H9N2 avian influenza virus subtypes do not affect postinfluenza secondary bacterial pneumonia
We investigated the synergism between influenza virus and Streptococcus pneumoniae, particularly the role of deletions in the stalk region of the neuraminidase (NA) of H2N2 and H9N2 avian influenza viruses. Deletions in the NA stalk (ΔNA) had no effect on NA activity or on the adherence of S. pneumoniae to virus-infected human alveolar epithelial (A549) and mouse lung adenoma (LA-4) cells, although it delayed virus elution from turkey red blood cells. Sequential S. pneumoniae infection of mice previously inoculated with isogenic recombinant H2N2 and H9N2 influenza viruses displayed severe pneumonia, elevated levels of intrapulmonary proinflammatory responses, and death. No differences between the WT and ΔNA mutant viruses were detected with respect to effects on postinfluenza pneumococcal pneumonia as measured by bacterial growth, lung inflammation, morbidity, mortality, and cytokine/chemokine concentrations. Differences were observed, however, in influenza virus-infected mice that were treated with oseltamivir prior to a challenge with S. pneumoniae. Under these circumstances, mice infected with ΔNA viruses were associated with a better prognosis following a secondary bacterial challenge. These data suggest that the H2N2 and H9N2 subtypes of avian influenza A viruses can contribute to secondary bacterial pneumonia and deletions in the NA stalk may modulate its outcome in the context of antiviral therapy. © 2012, American Society for Microbiology.Fil: Chockalingam, Ashok K.. University of Maryland; Estados UnidosFil: Hickman, Danielle. University of Maryland; Estados UnidosFil: Pena, Lindomar. University of Maryland; Estados UnidosFil: Ye, Jianqiang. University of Maryland; Estados UnidosFil: Ferrero, Andrea. University of Maryland; Estados UnidosFil: Echenique, Jose Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Chen, Hongjun. University of Maryland; Estados UnidosFil: Sutton, Troy. University of Maryland; Estados UnidosFil: Perez, Daniel R.. University of Maryland; Estados Unido
Entropy in the Classical and Quantum Polymer Black Hole Models
We investigate the entropy counting for black hole horizons in loop quantum
gravity (LQG). We argue that the space of 3d closed polyhedra is the classical
counterpart of the space of SU(2) intertwiners at the quantum level. Then
computing the entropy for the boundary horizon amounts to calculating the
density of polyhedra or the number of intertwiners at fixed total area.
Following the previous work arXiv:1011.5628, we dub these the classical and
quantum polymer models for isolated horizons in LQG. We provide exact
micro-canonical calculations for both models and we show that the classical
counting of polyhedra accounts for most of the features of the intertwiner
counting (leading order entropy and log-correction), thus providing us with a
simpler model to further investigate correlations and dynamics. To illustrate
this, we also produce an exact formula for the dimension of the intertwiner
space as a density of "almost-closed polyhedra".Comment: 24 page
Unfrustrated Qudit Chains and their Ground States
We investigate chains of 'd' dimensional quantum spins (qudits) on a line
with generic nearest neighbor interactions without translational invariance. We
find the conditions under which these systems are not frustrated, i.e. when the
ground states are also the common ground states of all the local terms in the
Hamiltonians. The states of a quantum spin chain are naturally represented in
the Matrix Product States (MPS) framework. Using imaginary time evolution in
the MPS ansatz, we numerically investigate the range of parameters in which we
expect the ground states to be highly entangled and find them hard to
approximate using our MPS method.Comment: 5 pages, 5 figures. Typos correcte
NuSTAR study of Hard X-Ray Morphology and Spectroscopy of PWN G21.5-0.9
We present NuSTAR high energy X-ray observations of the pulsar wind nebula
(PWN)/supernova remnant G21.5-0.9. We detect integrated emission from the
nebula up to ~40 keV, and resolve individual spatial features over a broad
X-ray band for the first time. The morphology seen by NuSTAR agrees well with
that seen by XMM-Newton and Chandra below 10 keV. At high energies NuSTAR
clearly detects non-thermal emission up to ~20 keV that extends along the
eastern and northern rim of the supernova shell. The broadband images clearly
demonstrate that X-ray emission from the North Spur and Eastern Limb results
predominantly from non-thermal processes. We detect a break in the spatially
integrated X-ray spectrum at ~9 keV that cannot be reproduced by current SED
models, implying either a more complex electron injection spectrum or an
additional process such as diffusion compared to what has been considered in
previous work. We use spatially resolved maps to derive an energy-dependent
cooling length scale, with . We find
this to be inconsistent with the model for the morphological evolution with
energy described by Kennel & Coroniti (1984). This value, along with the
observed steepening in power-law index between radio and X-ray, can be
quantitatively explained as an energy-loss spectral break in the simple scaling
model of Reynolds (2009), assuming particle advection dominates over diffusion.
This interpretation requires a substantial departure from spherical
magnetohydrodynamic (MHD), magnetic-flux-conserving outflow, most plausibly in
the form of turbulent magnetic-field amplification.Comment: 13 pages, 8 figures, 1 table, Accepted for publication in the
Astrophysical Journa
Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia
Abstract
Background
Previous work has demonstrated a strong association between lung injury in African American children with pneumonia and a polymorphic (TG)mTn region in cystic fibrosis transmembrane conductance (CFTR) involved in the generation of a nonfunctional CFTR protein lacking exon 9. A number of splicing factors that regulate the inclusion/exclusion of exon 9 have been identified. The objective of this study was to determine whether genetic variants in these splicing factors were associated with acute respiratory distress syndrome (ARDS) in children with pneumonia.
Methods
This is a prospective cohort genetic association study of lung injury in African American and non-Hispanic Caucasian children with community-acquired pneumonia evaluated in the emergency department or admitted to the hospital. Linkage-disequilibrium-tag single nucleotide polymorphisms (LD-tag SNPs) in genes of the following splicing factors (followed by gene name) involved in exon 9 skipping PTB1 (PTBP1), SRp40 (SFRS1), SR2/ASF (SFRS5), TDP-43 (TARDBP), TIA-1 (TIA1), and U2AF65 (U2AF2) were genotyped. SNPs in the gene of the splicing factor CELF2 (CELF2) were selected by conservation score. Multivariable analysis was used to examine association between genotypes and ARDS.
Results
The African American cohort (n = 474) had 29 children with ARDS and the non-Hispanic Caucasian cohort (n = 304) had 32 children with ARDS. In the African American group multivariable analysis indicated that three variants in CELF2, rs7068124 (p = 0.004), rs3814634 (p = 0.032) and rs10905928 (p = 0.044), and two in TIA1, rs2592178 (p = 0.005) and rs13402990 (p = 0.018) were independently associated with ARDS. In the non-Hispanic Caucasian group, a single variant in CELF2, rs2277212 (p = 0.014), was associated with increased risk of developing ARDS.
Conclusions
The data indicate that SNPs in CELF2 may be associated with the risk of developing ARDS in both African American and non-Hispanic Caucasian children with pneumonia and suggest that the potential role of the splicing factor CELF2 in ARDS should be explored further.http://deepblue.lib.umich.edu/bitstream/2027.42/134745/1/13054_2016_Article_1454.pd
A window to quantum gravity phenomena in the emergence of the seeds of cosmic structure
Inflationary cosmology has, in the last few years,received a strong dose of
support from observations. The fact that the fluctuation spectrum can be
extracted from the inflationary scenario through an analysis that involves
quantum field theory in curved space-time, and that it coincides with the
observational data has lead to a certain complacency in the community, which
prevents the critical analysis of the obscure spots in the derivation. We argue
here briefly, as we have discussed in more detail elsewhere, that there is
something important missing in our understanding of the origin of the seeds of
Cosmic Structure, as is evidenced by the fact that in the standard accounts the
inhomogeneity and anisotropy of our universe seems to emerge from an exactly
homogeneous andisotropic initial state through processes that do not break
those symmetries. This article gives a very brief recount of the problems faced
by the arguments based on established physics. The conclusion is that we need
some new physics to be able to fully address the problem. The article then
exposes one avenue that has been used to address the central issue and
elaborates on the degree to which, the new approach makes different predictions
from the standard analyses. The approach is inspired on Penrose's proposals
that Quantum Gravity might lead to a real, dynamical collapse of the wave
function, a process that we argued has the properties needed to extract us from
the theoretical impasse described above.Comment: 13 pages, 3 figures. To appear in DICE 2008 conference proceeding
On the symmetry of the vacuum in theories with spontaneous symmetry breaking
We review the usual account of the phenomena of spontaneous symmetry breaking
(SSB), pointing out the common misunderstandings surrounding the issue, in
particular within the context of quantum field theory. In fact, the common
explanations one finds in this context, indicate that under certain conditions
corresponding to the situation called SSB, the vacuum of the theory does not
share the symmetries of the Lagrangian. We explain in detail why this statement
is incorrect in general, and in what limited set of circumstances such
situation could arise. We concentrate on the case of global symmetries, for
which we found no satisfactory exposition in the existing literature, and
briefly comment on the case of gauge symmetries where, although insufficiently
publicized, accurate and complete descriptions exist. We briefly discuss the
implications for the phenomenological manifestations usually attributed to the
phenomena of spontaneous symmetry breaking, analyzing which might be affected
by our analysis and which are not. In particular we describe the mass
generation mechanism in a fully symmetric scheme (i.e., with a totally
symmetric vacuum), and briefly discuss the implications of this analysis to the
problem of formation of topological defects in the early universe
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